scienceofprevention Day 2
https://scienceofprevention.com/alz/alzheimers-epidemic/?inf_contact_key=a05806dedff6b0b98f5eae1a0795d96d09c74070ac2bf3cfa7869e3cfd4ff832
Host: David Perlmutter, MD, Board-Certified Neurologist & #1 NYT Bestselling AuthorEPISODE 1
OCTOBER 10: Untangling Alzheimer’s - What’s Going Wrong now!
- What is going wrong in the brain and, more importantly, why current medications do not work
- Signs & symptoms of Alzheimer’s disease
- The mechanisms that lead to the development of Alzheimer’s
- The anatomy of how this disease develops in the brain, how thinking becomes impaired, and why understanding this process is so important
- Which parts of the brain are affected by Alzheimer's, how drugs for this disease are supposed to work, and the reasons they don't
- How we diagnose Alzheimer’s and the way this disease progresses over time 
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- current standard of care for alz
- changes in the brain that accompany the development of alz
- why med establishment has struggled to develop meaningful teatments
- the need to develop a comprehensice plan for alz prevention
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- risk factors for alz and tests for your risk for developing alz
- how patients are diagnosed w/alz
- review std of care & treatment options
- cover the natural progression of alz
- why mainstream medicine is reluctant to embrace the fact that alz is a prevenetable disease
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- risk factors:
- - diabedies; if you have type-2 diabedies then your risk more than doubles
- - women are more likely than men to get alz by a ratio of 2:1
- - being overweight significantly increases the risk
- - everybody is at risk; if you are 85years old then you have a 50% chance of getting alz
- - 1 in 4 people carry genes that put you at risk
- - major risk factors:
- - - age, esp if over 65yrs old
- - - female
- - - diabedies or insulin resistance
- - - if overweight but not diabetic, then inflamation could trigger alz
- - major contributors to alz
- - - insulin resistance & obesity, predibedies and type=2 diabedies
- - singular most imp. risk factor
- - - age, viz., biological age
- - - - measurement of amount of damage your immune system has suffered
- - hormones
- - - women metabolize lipids & fats differently, glucose too
- - alz affects patient and care givers; care giver's die 60% faster
- labratory tests to determine risk:
- - genetic: genetic tests w/the counceling of a health care provider
- - metabolic: fasting blood sugar & fasting insulin level
- - inflamation: C-reactive-Protine is an inflamation marker
- alz diagnosis is multi-facited by a experienced team
- - neuropsychological tests, cognitive memory executive function types of tests
- - blood work
- - sophisticated brain imaging studies
- - - memory loss is prime idicator
- - - - if forget keys, that's aging
- - - - if forget what keys are for, that's a problem
- - - - attention, language, words, names
- - - - for women: can't multi-task
- once diagnosed, therapy begins 
- - typically manages symptoms, but not the cure or slow disease progression itself, and may cause worsening more quickly
- - std of care is that there is no std of care, i.e., get your affairs in order and good luck
- - drugs: effect is minimal, make people worse aggressivly over time
- - - none actually slow the disease
- 36 things contribute to alz, so, a drug that attacks 1 thing leaves 35 things left to correct
- alz begins w/subjective congitive impairment,... to mild cognitive imparinment, aka MCI
- - MCI is somewhere btwn normal aging and dementia, a high risk condition for alz
- - exercize can improve cognition
- mainstream med wants solutions that can be patented in a drug, but,
- - turns out life style solutions do work, but do NOT generate money for big pharma
- - and these ideas aren't taught in medial school s0 not embrased by main stream med
- preventable w/exercise, diet, lifestyle problems, managing stress, sleep, cardiometabolic risk factors
- important to reduce riskk and prevent alz in the 1st place
- - NEURO: Nugtrition, Exercise, Unwind or stress mgmt, Restorative sleep, Optimizing cognitive activity
- modifyable risks:
- - diet, super inflamatory in America
- - lack of exercise is inf.
- - stress is inf.
- - not sleeping is inf.
- - nutritionally defficient is inf.
- - having toxins is inf.
- - having bad gut microbiom is inf.
- - correcting these lead to reduction of inf and healing of the brain
- start nutrition correction and reduce risk by 50%
- start exercise and reduce risk by 48%

KF!